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AMRIS Science Highlights

The proposed structure of the DNA fZ-motif (left) with a negatively charged reverse dZ:dZ- base pair (right) that forms over the pH range of 8.0 to 9.0

September 12, 2024

Scientists can create synthetic imitations of natural polymers, such as DNA, which provide an understanding of how nature works and can confer unique …


Figure

June 20, 2024

Deuterated water (2H2O) is often used to examine metabolic pathways in humans and animals. However, it can cause toxicity and distort metabolic readin…


Effectiveness factor of nanoporous gold catalysts exhibiting different shapes and characteristic lengths (L).

October 18, 2023

For the first time, NMR diffusion measurements have been successfully used in a metallic catalyst, examining gas exchange rates in nanoporous gold. Th…


Receptor proteins respond differently to drugs depending on the environment in which they are studied.

May 24, 2023

Special protein-coupled receptors play a role in nearly all physiological responses and are targets for more than 1/3 of all FDA-approved drugs. State…


The colored regions of the protein in the above schematic were revealed to be interacting with the polymer

December 12, 2022

Using NMR, researchers determined a molecular model of a protein-polymer conjugate, providing new insights into how polymers can be used to make prote…


Diffusion MR microscopy of a sea slug neuron at 7.8 μM resolution (left) The cellular structures can also be identified using 40X traditional light microscopy (right).

September 12, 2022

MRI scans taken after a stroke show brightness around the injury, the origins of which have been a long-standing and vexatious mystery for scientists.…


Peatland locations and sites tested

May 16, 2022

Understanding the organic composition of peat wetland soils can determine whether the carbon sources may be converted into carbon dioxide gas, work th…


Epidural electrode grid C3–C5 with three bipolar (A1, A2, and A3) and three monopolar configurations (B1, B2, and B3); actual wire width is 25 µm.

September 22, 2021

Respiratory insufficiency is a leading cause of death due to drug overdose or spinal cord injuries. The diaphragm can be stimulated using temporal int…


The representative stacked spectra in each set are from metabolic stages of pupae during the dormancy period: A) interbout of metabolic arousal (IBA), B) early metabolic depression, and C) late metabolic depression.

May 28, 2021

An insect's ability to survive anaerobic conditions (without oxygen) during winter pupation occurs through periodic cycling of aerobic respiration pat…


Overall hepatic metabolism is significantly altered by diet.

November 18, 2020

Non-alcoholic Fatty Liver Disease and its progression to more serious diseases will become the main cause for liver transplant in the next 5 years. He…


Metabolism pathways of [2H7]glucose (green stars), with red dots marking the presence of 2H, and larger dots indicating two 2H atoms. Note that HDO (gold stars) can be produced at multiple steps in the glycolytic pathway.

September 01, 2020

Magnetic resonance of cancer cell metabolism is a novel technique to discern between cancerous and normal liver cells, providing a promising approach …


Resting state functional MRI at 11.1T revealed the effects on brain microstructures and intrinsic activity due to β-amyloid (Aβ) plaque deposits and inflammation, as indicated by the presence of the inflammatory protein interleukin-6 (IL6).

March 23, 2020

Magnetic Resonance Imaging (MRI) of mouse models for Alzheimer’s disease can be used to determine brain response to plaque deposits and inflammation t…


Actual MRI cross-section of the mouse brain, showing injection site

January 23, 2020

Little is known about the path of metabolic waste clearance from the brain. Here, high-field magnetic resonance images a possible pathway for metaboli…


Three genotypes of Acropora cervicornis from an established coral nursery near Tavernier, FL used in this study.

May 15, 2019

Three variants of the coral species A cervicornis were found to have unique metabolic signatures that can be distinguished by NMR spectroscopy. Differ…


Schematics of ethane diffusion in ZIF-7-8

March 01, 2019

Combining high-field NMR with infrared microscopy, scientists learned more about how gas diffuses in a novel class of molecular sieves that could one …


Left: pH-sensitive ratiometric response. Right: A pH map.

July 10, 2018

A new pH sensitive contrast agent for MR imaging has been developed that produces image contrast based on the local pH and that has great potential fo…


Images show (left to right for two different stimulations) the standard MR image, measured electrical current distribution overlaid on MR image, measured electrical current density alone, and simulated current distribution.

May 18, 2018

Scientists measured the first in vivo images of stimulated current within the brain using an imaging method that may improve reproducibility and safet…